AGUINALDO, Alicia M.

AGUINALDO, Alicia M.

Academic Qualifications

Research Highlights

Research Interests

Academic Qualifications

Degrees

  • Doctor of Philosophy in Chemistry, University of the Philippines – Diliman, Quezon City, Philippines, 1992
  • Master of Science in Chemistry, University of Santo Tomas – Manila, Philippines, 1982
  • Bachelor of Science in Chemistry, University of Santo Tomas – Manila, Philippines, 1976

Research Highlights

  • Identification of plant compounds inhibiting Mycobacterium tuberculosis H37Rv, from selected species of Apocynaceae, Rutaceae, Zingiberaceae, Rubiaceae, Moraceae, Ebenaceae, Lecithydaceae, Verbenaceae and Cucurbitaceae

Research Interests

  • Chemistry of natural products with antitubercular property, and antidiabetic property
  • Phytochemistry of Philippine plants
  • Chemical transformations of natural products for structure – activity relationships
  • Chemistry of microbial metabolites

Courses Handled

Major Recognitions

Professional Activities

Courses Handled

Major Recognitions

  • 2019 Philippine Federation of Chemistry Societies (PFCS) – Shimadzu Achievement Award for Chemical Research, May 28, 2019, at the Pacific Grand Ballroom, Waterfront Hotel  & Convention Center, Lahug, Cebu City
  • 3rd Place, Best Poster Award, Bioassay Guided Isolation of a-Glucosidase Inhibitors from the Methanolic Bark Extract of Ceriops tagal C.B.Rob. (B Canusa, O Villaflores, V Wagh, M Korinek, Y Tsai, FR Chang, AM Aguinaldo), 2nd International and 9th Annual National Convention, Philippine Society for Cell Biology, University of Santo Tomas, Manila, Oct 22-23, 2018
  • 2011 NRCP Achievement Award (Chemical Sciences), March 2012 (Department of Science and Technology)
  • 1993 Outstanding Young Scientist of the Philippines (National Academy of Science and Technology, Philippines)

Professional Activities

  • Chairman of the Division of Chemical Sciences, National Research Council of the Philippines (2005-2010)
  • President (1996-2001), Vice-President (2011-2013), Board Member (2002-2004, 2014-2016), Auditor (2005-2007, 2008-2010), Natural Products Society of the Philippines
  • Vice-President (1998-2000), Public Relations Officer (2000-2002), External Vice-President (2002-2015), Organic Chemistry Teachers Association of the Philippines
  • Vice-President, Philippine Federation of Chemistry Societies (2003-2005)
  • ReviewerPhytochemistry Letters, International Journal of Molecular Sciences, MOLECULES, Acta Pharmaceutica, NRCP Research Journal, Philippine e-Journal for Applied Research and Development, Pharmaceutical Biology, Studies in Natural Products Chemistry (Bioactive Natural Products)
  • Field Editor for Natural Products, KIMIKA (2013-present)

Selected Publications

Selected Publications

  • Garcellano RC, Cort JR, Moinuddin SGA, Franzblau SG, Ma R, Aguinaldo AM. (2019) An iboga alkaloid chemotaxonomic marker from endemic Tabernaemontana ternifolia with antitubercular activity, Natural Product Research, DOI:10.1080/14786419.2018.1550759
  • Garcellano RC, Moinuddin SGA, Young RP, Zhou M, Bowden ME, Renslow RS, Yesiltepe Y, Thomas DG, Colby SM, Chouinard CD, Nagy G, Attah IK, Ibrahim YM, Ma R, Franzblau SG, Lewis NG, Aguinaldo AM, Cort JR. (Oct 8, 2018) Isolation of Tryptanthrin and Reassessment of Evidence for Its Isobaric Isostere Wrightiadione in Plants of the Wrightia Genus. Journal of Natural Products 82 (3), pp 440–448. DOI: 10.1021/acs.jnatprod.8b00567
  • Garcellano RC, Dahse HM, Franzblau SG, Wang Y, Aguinaldo AM. (2018). Preliminary Phytochemical Screening and Evaluation of Antiproliferative, Cytotoxic and Antituberculosis Activities of Three Apocynaceae Plants Endemic to Palawan, Philippines. Our Palawan 4: 21-30.
  • Galang MGM, Macabeo APG, Chang WC, Isobe M, Aguinaldo MAM. (2016) Glucosides from the Unripe Fruit Juice of Carica papaya Linn. (Caricaceae) Cultivar “Red Lady” with Antioxidant Activity. Journal of Functional Foods 22: 358–362
  • Macabeo APG, Villaflores OB, Franzblau SG, Aguinaldo MAM. (2016) Natural products-based discovery of antitubercular agents from Philippine medicinal plants — A review. Acta Manilana 64: 87-98
  • Lirio SB, Macabeo APG, Paragas EM, Knorn M, Kohls P, Franzblau SG, Wang Y, Aguinaldo MAM. (2014) Antitubercular constituents from Premna odorata Blanco. Journal of Ethnopharmacology 154:471-474
  • Vidar, WA, Macabeo APG, Knorn M, Kohls P, Aguinaldo AM. Polymethoxylated flavones from Micromelum compressum. Biochemical Systematics and Ecology 50 (2013) 48-50.
  • Lawag, IL., Aguinaldo, AM, Naheed, S., and Mosihuzzaman, M. a-Glucosidase inhibitory activity of selected Philippine plants. J. Ethnopharmacol. 144 (Oct 2012) 217-219. ISSN 0378-8741
  • Panlilio, BG.,. Macabeo, APG., Knorn, M., Kohls, P., Richomme, P., Kouam, SF., Gehle, D., Krohn, K., Franzblau, SG., Zhang, Q., and Aguinaldo, AM. (Sept 2012) A lanostane aldehyde from Momordica charantia. Phytochemistry Letters 5 (3) 682-684. ISSN 1874-3900
  • Macabeo, APG, Gehle, D, Krohn, K., Franzblau, SG, and Aguinaldo, AM. (June 2012) Photoactivated [3+2] Addition of 6,7-seco-Angustilobine B to Fullerene [C60]. Natural Product Communications 7(6), 743-745. ISSN 1934-578X (printed); 1555-9475 (online)
  • Macabeo, APG, Vidar, WS, Chen, X, Decker, M, Heilmann, J, Wan, B, Franzblau, SG, Galvez, EV, Aguinaldo, AM, Cordell, GA. (2011) Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa. European Journal of Medicinal Chemistry 46: 3118-3123
  • Villaflores, O, Macabeo, APG, Gehle, D, Krohn, K, Franzblau, SG, and Aguinaldo, AM. (Oct-Dec 2010) Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis, Pharmacognosy Magazine, 6 (24), 339-344
  • Villaflores OB, Billones S, Quinto E, Franzblau S, and Aguinaldo A. Phytochemical Screening and Evaluation of the Genotoxicity and Antimycobacterial Activity of Wrightia antidysenterica Leaf Extract. Acta Manilana 57 (2009) 51-56.
  • Macabeo APG and Aguinaldo AM. (Jul-Dec 2008) Chemical and Phytomedicinal Investigations in Lunasia amara”. Phcog Rev. 2 (4), 317-325
  • Macabeo APG, Krohn K, Gehle D, Read RW, Brophy JJ, Franzblau SG, Aguinaldo AM. (2008) Activity of the Extracts and Indole Alkaloids from Alstonia scholaris Against Mycobacterium tuberculosis H37RV. Philipp Agric Scientist 91 (3), 348-351.
  • Macabeo APG, Villafranca M, Aguinaldo A, Hussain H, Krohn K. (Aug 2008) Clerosterols from Clerodendrum quadriloculare. Biochemical Systematics and Ecology 36 (8), 659-660.
  • Aguinaldo AMA. (2007) Selected Zingiberaceae Species Exhibiting Inhibitory Activity against Mycobacterium tuberculosis H37Rv: A Phytochemical Profile. Gardens’ Bulletin Singapore 59 (1&2), 13-22.
  • Panlilio BG, Franzblau SG, Aguinaldo AM. (Dec. 2007) Variability of the Antitubercular Activity of Ampalaya (Momordica charantia L.) from Selected Provinces in Luzon, Philippines. The Philippine Agricultural Scientist 90 (4), 337-340.
  • Mandap K, Marcelo R, Macabeo A, Yamauchi T, Abe F, Franzblau S, and Aguinaldo A. (2007). Antitubercular phenyldecanoids from the Philippine ginger (Zingiber officinale). ACGC Chem. Res. Comm 21, 20-22.
  • Aguinaldo A, Dalangin-Mallari V, Macabeo A, Byrne L, Abe F, Yamauchi T, and Franzblau S. (2007) Quinoline alkaloids from Lunasia amara inhibit Mycobacterium tuberculosis H37Rv in vitro. International Journal of Antimicrobial Agents 29, 744-746.
  • Tudla F, Aguinaldo A, Krohn K, Hussain H, and Macabeo A. (Jan 2007). Highly oxygenated cyclohexene metabolites from Uvaria rufa. Biochemical Systematics and Ecology 35 (1), 45-47.
  • Macabeo A, Byrne LT, Franzblau SG, and Aguinaldo AM. (2006). 19E-Akuammidine from the Antimycobacterial Alkaloid Fraction of Alstonia scholaris Leaves. Asian Coordinating Group for Chemistry Chem. Res. Comm. 20, 11-13.
  • Macabeo A, Krohn K, Gehle D, Read R, Brophy J, Cordell G, Franzblau S, Aguinaldo A. (2005) “Indole Alkaloids from the Leaves of Philippine Alstonia scholaris.” Phytochemistry 66, 1158-1162.
  • Aguinaldo A, Padolina W, Abe F and Yamauchi T. (2003) “Flavonoids from Mikania cordata.” Biochemical Systematics and Ecology 31, 665-668.
  • Saludes J, Garson M, Franzblau S, and Aguinaldo A. (2002) “Antitubercular Constituents from the Hexane Fraction of Morinda citrifolia Linn. (Rubiaceae).” Phytotherapy Research 16, 683-685.
  • Macabeo A, Franzblau S, Cordell G, and Aguinaldo A. (1999) “A Plumeran Indole Alkaloid from the Bioactive Antitubercular Fraction of Catharanthus roseus [L.] G. Don [Apocynaceae].” Acta Manilana 47, 53-39.
  • Aguinaldo A. (Contributor), Plant Resources of South-East Asia, No. 12 (1), Medicinal and poisonous plants 1. L. de Padua, N. Bunyapraphatsara and R. Lemmens (Eds.), Backhuys, Leiden (1999)
  • Aguinaldo A. “The Search for Antituberculars: A Phytochemical Approach.” Proceedings, 1999 Annual Scientific Sessions, “Basic Research for New Horizons in Science and Technology.” NRCP, Gen. Santos, Bicutan, Taguig, Metro Manila 1631
  • Aguinaldo A, Espeso E, Estrada B, Garcia , Guevara B and Nonato M. (1998) Alkaloids. In Philippine Science Encyclopedia, National Research Council of the Philippines, Manila.
  • Aguinaldo A, Armstrong J, Cannon J, Colegate S, Comber M, Marchant N, Sargent M. (1996) Stoechadone: a New Naphthoquinone from Conospermum stoechadis. Austr. J. Chem. 49, 197-8.
  • Villaraza C, Aguinaldo A, Gonzales M, Guevara B, Tagoc N, Gray A. (1995) The Major Compounds Isolated from the Antibacterial Fraction of the Leaf Extract of Tabernaemontana pandacaqui Poir. Acta Manilana 43, 9-17.
  • Aguinaldo A, Abe F, Yamauchi T and Padolina W. (1994) The Germacranolides from Mikania cordata. Phytochemistry 38 (6), 1441-1443
  • Aguinaldo A, Ocampo O, Bowden B, A Gray and Waterman P. (1993) Tectograndone, an Anthraquinone-Naphthaquinone Pigment from the Leaves of Tectona grandis. Phytochemistry 33 (4), 933-35
  • Aguinaldo AM, Read RW. (1990) A Major Piperidine Alkaloid from Microcos philippinensis. Phytochemistry 29 (7), 2309-13
  • Aguinaldo A, Claustro A, Recio B, Cadelina N and Guevara B. (1984). Alkaloid Field Survey in Selected Areas of Luzon, Philippines. Acta Manilana 23 (33), 39-78

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