ASIS, Leilani M.

 ASIS, Leilani M.

Prof. Leilani B. Mercado-Asis received her B.S. Medical Technology and Medicine degrees from the University of Santo Tomas in Manila in 1977 and 1981, respectively. She received her Ph.D. in Endocrinology and Metabolism at Gifu School of Medicine in Gifu, Japan, in 1992 and Masteral degree in Public Health from the University of the Philippines Open University in Manila in 2010. She completed Masteral studies in Distance Education major in Instructional Design at Athabasca University in Canada in 2020. Her primary research interests and original studies involve secondary hypertension due to pheochromocytoma, paraganglioma, and primary hyperaldosteronism, pathophysiology and clinical and public health implications of pre-impaired glucose tolerance, and medical nutrition therapy in type 2 DM using automatic snacking. She conceptualized and established innovative approaches for excellent glycemic control of diabetes through PRN (as needed) insulin injection both for patients on anti-DM tablets and insulin injection, an economical approach of treatment for benign nontoxic multinodular goiter using serial 131Iodine therapy, characterization of postprandial dyslipidemia among Filipinos and use of orlistat to address the problem. She has received national and international recognition for her scientific undertakings and authored and co-authored scientific work published in notable peer-reviewed journals. Prof. Mercado-Asis has recently engaged in medical education research. She developed Target-Oriented Clinical Skill Enhancement (TOCSE), a teaching and learning tool that connects didactic knowledge to clinical application.

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UST fetes 127 researchers, concludes Research Fortnight 2023

UST fetes 127 researchers, concludes Research Fortnight 2023

The University of Santo Tomas honored its researchers from various…

UST recognizes research achievements of faculty

UST recognizes research achievements of faculty

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Prof. Leilani B.  Mercado-Asis, MD, PhD, MPH, MEd (DE), FPCP, FPSEM

Faculty of Medicine and Surgery

lmasis@ust.edu.ph

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Academic Qualifications

Research Highlights

Research Interests

Academic Qualifications

Degrees

  • Master of Distance Education, major in Instructional Design, Athabasca University, Alberta, Canada, 2017-2020  
  • Master of Public Health, major in Biostatistics, University of the Philippines Open University, 2009-2012 
  • Doctorate in Endocrinology and Metabolism, Gifu University School of Medicine, Japan, 1987-1992
  • Doctor of Medicine, University of Santo Tomas – Manila, Philippines, 1977-1981
  • Bachelor of Science in Medical Technology, University of Santo Tomas – Manila, Philippines, 1973-1977

Postgraduate Trainings  

  • Graduate Certification in Distance Education, University of the Philippines Open University, 2013-2016
  • Post-doctoral Fellowship in Basic and Clinical Endocrinology, National Institutes of Health, Bethesda, Maryland, USA, 1992-1995   
  • Residency in Internal Medicine, University of Santo Tomas Hospital – Manila, Philippines, 1983-1986 

Research Highlights

  • Her research highlights include secondary hypertension due to pheochromocytoma, paraganglioma and primary hyperaldosteronism, pathophysiology and clinical and public health implications of pre-impaired glucose tolerance, and medical nutrition therapy in type 2 DM using automatic snacking. She established innovative approaches for excellent glycemic control of diabetes through PRN (as needed) insulin injection both for patients on anti-DM tablets and insulin injection and economical approach of treatment for benign nontoxic multinodular goiter using serial 131Iodine therapy. She characterized postprandial dyslipidemia among Filipinos and demonstrated use of orlistat to address the problem. Prof. Mercado-Asis has recently engaged in medical education research. She developed Target-Oriented Clinical Skill Enhancement (TOCSE), a teaching and learning tool, which connects didactic knowledge to clinical application.

Research Interests

  • Endocrinology
  • Diabetes and Metabolism
  • Neuroendocrine Tumors
  • Secondary Hypertension Medical Education

Courses Handled

Major Recognitions

Professional Activities

Courses Handled

  • Medicine 1 – Physical Diagnosis (2nd year Medical Students)
  • Medicine 2 (3rd year Mdical Students)
  • Medicine 3 – Clerkship (4th year Medical Students)

Major Recognitions

  • Gusi Peace Prize International Awardee in Medical Education, Research, and Patient Care & Service, 2017 
  • Dr. Cyrus Katzen Pheochromocytoma and Paraganglioma Humanitarian Award, Washington, D.C. USA, 2012
  • Dangal ng UST Award 2013 (Gawad Benavides – 20 years in service)
  • Dangal ng UST Award 2004 (Gawad San Alberto Magno Awardee – Outstanding Researcher in the Health Sciences)
  • UST Rector’s Gold Awardee in Research, 1999, 2000, 2002 and 2004, 2006, 2008, 2010,2012, 2014 
  • UST  Rector’s International Publication Award, 2004, 2006, 2012, 2014, 2016, 2017 
  • Gold Series Award, 2016-2018, 2018-2020 
  • Silver Series Award, 2020-2022 

Professional Activities

Academic Appointment

  • Professor 1, Department of Medicine, UST Faculty of Medicine & Surgery 

Administrative Appointments/Positions  

  • Program Director, Master in Public Health International, 2018-present 
  • Board of Director, World Hypertension League 

Past Positions 

  • President, Philippine Thyroid Association, 2006-2008
  • President, Osteoporosis Society of the Philippines, Inc, 2009-2010
  • President, Philippine College of Endocrinology, Diabetes and Metabolism, 2010-2011
  • Chairman, Department of Medicine, UST Faculty of Medicine and Surgery 2010-2012 
  • President, Asian Federation of Osteoporosis Societies 2017-2019 
  • President, Philippine Society of Hypertension, 2019-202 

Professional Affiliations  

  • Life Fellow, Philippine College of Physicians
  • Fellow, Philippine College of Endocrinology, Diabetes and Metabolism

Hospital Affiliations  

  • University of Santo Tomas Hospital
  • Baypointe Hospital and Medical Center
  • James L. Gordon Memorial Hospital

Selected Publications

Selected Publications

  • Healthcare Challenges in the Management of Primary Aldosteronism in Southeast Asia
  • Postprandial Effect of Orlistat on the Peaking of Lipid Level (PEOPLE) After Sequential High Fat Meal: A Randomized, Double- Blind Placebo Controlled Trial
  • A Comparison of Dose Response Postprandial Lipid Profile of Healthy Filipino Subjects After an Oral Fat    Challenge Test of Varying Fat Contents.
  • Pathophysiology and mechanisms of hypertension (Asian Context). Book Chapter
  • Evolving clinical presentation and assessment of pheochromocytoma: A Review.
  • Clinical Presentation, Diagnosis, and Management of Primary Aldosteronism and Pheochromocytoma.
  • Pheochromocytoma: A Genetic and Diagnostic Update
  • Pheochromocytoma/paraganglioma: recent updates in genetics, biochemistry, immunohistochemistry, metabolomics, imaging and therapeutic options.
  • Clinical, diagnostic, and treatment characteristics of SDHA-related metastatic pheochromocytoma and paraganglioma.
  • The value of systemic hormonal unloading in pheochromocytoma.
  • Clinical characteristic and outcomes of SDHB-related pheochromocytoma and paraganglioma in children and adolescents.
  • Medical education through distance education: How does it work?
  • Clinical characteristic and outcomes of SDHB-related pheochromocytoma and paraganglioma in children and adolescents.
  • A prospective randomized, open label, single-center study for assessment of safety and effectiveness of recombinant human insulin 30/70 plus insulin glulisine compared to recombinant human insulin NPH plus regular insulin in the management of type 2 diabetes mellitus patients in the Philippines.
  • Correlation of glycosylated hemoglobin and oral glucose tolerance test results in hyperinsulinemic pre-impaired glucose tolerance state versus normoinsulinemic-normal OGTT. 16. Postprandial lipemia is significantly correlated with postprandial hyperglycemia and poor glycemic control among patients with type 2 diabetes mellitus.
  • Successful Reduction in the size of cystic thyroid nodules with 131iodine therapy.
  • A randomized double-blind comparison of fixed versus calculated radioiodine dose regimen in the treatment of graves’ hyperthyroidism.
  • Removal of dominant adrenal lateralized by glucagon-stimulated adrenal venous sampling alleviates hypertension in bilateral pheochromocytoma.
  • Postprandial peaking and plateauting of trglyceride and VLDL were observed in patients with cardiovascular disease maintained on low fat diet and statin treatment.
  • Automatic snacking prevents hypoglycemia among outpatient type 2 diabetic patients on intensive insulin therapy.
  • 131 Iodine therapy is effective in the management of diffuse and nodular non-toxic goiter
  • Diagnosis of small adrenal pheochromocytoma by adrenal venous sampling with glucagon stimulation test.