MACABEO, Allan Patrick G.

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MACABEO, Allan Patrick G.

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MS Chemistry students win awards for biological, health sciences paper, poster presentations

Three Master of Science in Chemistry students of the UST…

International Collaboration on Toxicology and Pharmacology

Macabeo of Chemistry, RCNAS secures Humboldt fellowship grant for drug discovery

Dr. Allan Patrick Macabeo, a faculty member of the Department…

Prof. Allan Patrick G. Macabeo, Dr. rer. nat.

Department of Chemistry | College of Science | Research Center for the Natural and Applied Sciences

agmacabeo@ust.edu.ph | allanpatrick_m@yahoo.com | AllanPatrick.Macabeo@helmholtz-hzi.de

+63-967-206-7153 | +63-2-8252-4257

Academia.edu | ResearchGate | Google Scholar

Academic Qualifications

Research Highlights

Research Interests

Academic Qualifications

Degrees

Doctor of Natural Sciences (Magna cum Laude), Universität Regensburg – Germany, 2011
Master of Science in Chemistry (Magna cum Laude), University of Santo Tomas – Manila, Philippines, 2003
Bachelor of Science in Chemistry, University of Santo Tomas – Manila, Philippines, 1999

Research Highlights

Natural products-driven drug discovery of thirty novel/new biologically active agents from Philippine medicinal plants and saprobic/endophytic fungi with antimicrobial, antiviral, anti-cholinesterase, anti-glucosidase, anti-lipase, anti-tyrosinase, and cytotoxic activities.
Library synthesis of Michael acceptor system-containing compounds with profound cytotoxic, anti-infective and anti-cyclooxygenase activities.
Synthetic application of furan-derived cyclopropanes as intermediates in constructing complex g-butyrolactone natural products.

Research Interests

Isolation and total synthesis of complex natural products
Furans and cyclopropanes in organic synthesis
Synthetic methodology development and diversity-oriented synthesis (DOS)
Asymmetric catalysis and sp3 C-H activation
Medicinal Chemistry and computer-assisted drug discovery

Courses Handled

Major Recognitions

Professional Activities

Courses Handled

Graduate Level

Heterocyclic Chemistry
Organic Synthesis

Undergraduate Level

Biochemistry
Bioorganic Chemistry
General Chemistry
Organic Chemistry

Major Recognitions

Alexander von Humboldt Postdoctoral Research Fellow
German Academic Exchange (DAAD) Fellow
2017 UST Dangal Hall of Fame Awardee
2015 Outstanding Young Scientist of the Philippines (Organic Chemistry) (NAST Philippines)
2015 The World Academy of Sciences (TWAS) Award for Young Scientists (Organic Chemistry) (NAST Philippines)
ASEAN Young Scientist and Technologist Award (AYSTA), First Runner-Up, 2014 (ASEAN)
Merck Young Scientist Award in the Health Sciences, 2013 (Merck Inc.)
NAST Talent Search for Young Scientists, 2013 (NAST Philippines)

Professional Activities

Coordinator – UST College of Science International Relations Committee
Editorial Board Member – Pharmacognosy Research (MedKnow Pub), Philippine Journal of Health Research and Development (PJHRD) (UP Manila)
Reviewer — Journal of Natural Products (American Chemical Society); Journal of Agricultural and Food Chemistry (American Chemical Society); Journal of Ethnopharmacology (Elsevier); Studies in Natural Products Chemistry (Elsevier); Phytochemistry Letters (Elsevier); European Journal of Medicinal Chemistry (Elsevier); Current Organic Chemistry (Bentham Science); Current Organic Synthesis (Bentham Science); Letters in Drug Discovery and Design Chemistry (Bentham Science); Natural Products Research (Taylor and Francis) Spectroscopy Letters (Taylor and Francis); Records of Natural Products (ACG)
Project Leader – Research studies funded by the Alexander von Humboldt Foundation, International Foundation for Science (2 projects), Philippine Council for Health Research and Development (4 projects) and National Academy of Science and Technology for Outstanding Achievements in Science (2 projects)

Selected Publications

MTJ Quimque, M Mandigma, JAK Lim, S Budde, HM Dahse, OB Villaflores, AV Hallare, APG Macabeo. 2020. “Synthesis, characterization, and molecular docking studies of N-acylated butyro- and valerolactam derivatives with antiproliferative and cytotoxic activities”. Letters in Drug Design and Discovery, in press.
APG Macabeo, AIG Flores, RAT Fernandez, S Budde, C Faderl, HM Dahse, SG Franzblau. 2020. “Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora”. Natural Products Research, in press.
A Mapook, APG Macabeo, B Thongbai, KD Hyde, M Stadler. 2020. “Polyketide-derived secondary metabolites from a Dothideomycetes fungus, Pseudopalawania siamensis gen. et sp. nov., (Muyocopronales) with antimicrobial and cytotoxic activities”. Biomolecules 10: 569-592. (shared co-main authorship)
APG Macabeo, LAE Pilapil, KYMGarcia, MTJ Quimque, C Phukhamsakda, AJC Cruz, KD Hyde, M Stadler. 2020. “Alpha-glucosidase and lipase-inhibitory phenalenones from a new species of Pseudolophiostoma originating from Thailand”. Molecules 25:, 965-976.
APG Macabeo, AJC Cruz, A Narmani, M Arzanlou, A Babai-Ahari, LAE Pilapil, KYM Garcia, V Huch, M Stadler. 2020. “Tetrasusbtituted a-pyrone derivatives from the endophytic fungus, Neurospora udagawae”. Phytochemistry Letters 35: 147-151.
C Phukhamsakda, APG Macabeo, T Cheng, V Huch, KD Hyde, M Stadler. 2019. “Sparticolins A–G, biologically active spirodioxynapthalene derivatives from the ascomycocete Sparticola junci”. Journal of Natural Products 82: 2878-2885. (shared co-main authorship)
APG Macabeo, M Stadler. 2019. “Fungal-derived natural products inhibitory to human pathogenic viruses (section 9). The amazing potential of fungi: 50 ways we can exploit fungi industrially”. Fungal Diversity 1-136.
W Kuephadungphan, APG Macabeo, JJ Luangsa-ard, K Tasanathai, D Thanakitpipattana, S Phongpaichit, K Yuyama, M Stadler. 2019. “Studies on the biologically active secondary metabolites of the new spider parasitic fungus Gibellula gamsii”. Mycological Progress 1-12. (shared co-main authorship)

The University of Santo Tomas is one of the leading private research universities in the Philippines and is consistently ranked among the top 1000 universities in the whole world. With academic degrees and research thrusts in the natural, health, applied, social, and sacred sciences, as well as business and management, the University continuously strives to make a positive impact on the society.

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